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IGF-1 LR3 also has a significantly longer half-life than IGF-1
In the SOUL trial, published in March 2025 in the New England Journal of Medicine , researchers studied 9,650 participants aged 50 and older with type 2 diabetes and either cardiovascular or kidney disease
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The top 10 most strongly regulated genes included the elongation of very long chain fatty acids protein 6 (Elovl6), ephrin type-B receptor 2, cell death-inducing DFFA-like effector A, malic enzyme 1, arrestin domain-containing 3, fatty acid synthase (Fasn), ACC a (Acaca), cytochrome P450 3A41A, cytochrome P450 4A12B and metallothionein 1
Because it is a Schedule IV medication, its use requires careful screening, monitoring, and follow-up
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